Devastated by her recent divorce, Sabrina Matthews returns to Savannah, Georgia, with her eight-year-old daughter in tow. Fed up with the uncertainty of romance, the struggling single mother vows never to open her heart to the possibility of love gone wrong again. But then she meets Malcolm Winters, a prominent cardiologist. He too is reeling from a personal crisis. Malcolm finds it hard to fight the desire Sabrina stirs within him - will he be the man who convinces Sabrina to never say never again?